NOSO-502_product_DataBase

Bioactivity	NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties[1].
Invitro	NOSO-502 (16 µg/mL 和 32 µg/mL；24 h) 使大肠杆菌 ATCC 25922 和肺炎克雷伯菌 ATCC 43816 菌株对 NOSO-502 产生抗性[1]。NOSO-502 (100 µM) 降低了 HRPTEpiC 细胞活性，但不显著增加热休克蛋白 27 (HSP27) 和肾损伤分子 1 (KIM-1) 的表达[1]。NOSO-502 的体外抗菌活性[1]
In Vivo	NOSO-502 (1.3-40 mg/kg；皮下注射；单剂量) 在感染大肠杆菌 EN122 的 NMRI 小鼠中显示出抗菌作用[1]。NOSO-502 (4-24 mg/kg；皮下注射；单剂量) 在感染大肠杆菌 UTI89 的 C3H/HeN 小鼠中显示出保护作用[1]。NOSO-502 (2-80 mg/kg；皮下注射；单剂量) 在感染肺炎克雷伯菌 NCTC 13442 的 CD-1/ICR 小鼠中显示出保护作用[1]。NOSO-502 的药代动力学 (PK) 参数[1]Species
Name	NOSO-502
CAS	1894081-09-4
Formula	C47H80FN17O11
Molar Mass	1078.24
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Racine E, et al. In Vitro and In Vivo Characterization of NOSO-502, a Novel Inhibitor of Bacterial Translation. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e01016-18.

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