| Bioactivity | NOS-IN-3 (Compound 9a) is a potent, selective, imidamide derived NOS inhibitor with an IC50 against iNOS of 4.6 µM, without inhibiting eNOS. NOS-IN-3 has little toxicity and can be studied in the treatment of inducible isoform involved diseases, such as septic shock[1]. |
| Target | IC50: 4.6 µM (iNOS), > 1000 µM (nNOS) |
| Invitro | NOS-IN-3 (Compound 9a) shows high iNOS selectivity without eNOS inhibition activity [1].NOS-IN-3 (0-100 µM, 30 min) has little toxicity[1]. Cell Viability Assay[1] Cell Line: |
| Name | NOS-IN-3 |
| CAS | 2761725-68-0 |
| Formula | C10H15N3O |
| Molar Mass | 193.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fabio Arias, et al. Bioactive imidamide-based compounds targeted against nitric oxide synthase. Bioorg Chem. 2022 Feb 2;120:105637. |