| Bioactivity | NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively[1]. |
| Target | IC50: 0.1 μM (hiNOS), 1.1 μM (heNOS), and 0.2 μM (hnNOS) |
| In Vivo | Following oral administration, NOS-IN-1 (compound 3; 10 mg/kg) decreases serum nitrite/nitrate levels in an in vivo rat endotoxin assay[1]. |
| Name | NOS-IN-1 |
| CAS | 165383-72-2 |
| Formula | C8H16N2O2 |
| Molar Mass | 172.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. R K Webber, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101. |