NOD1 antagonist-2

CAS: F: C21H13Cl2F2N3O5S2 W: 560.38

NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse NOD1. NOD1 antagonist-2

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Bioactivity	NOD1 antagonist-2 (compound 66) is an orally active selective antagonist of both human and mouse NOD1. NOD1 antagonist-2 (compound 66) antagonizes NOD1-induced NF-κB and MAPK pathways[1].
Invitro	NOD1 antagonist-2 (compound 66) 在对HEK293细胞中的h/mNOD1诱导的NF-κB激活表现出有前景的拮抗活性 (IC50 分别为0.8 nM和32 nM)[1]。NOD1 antagonist-2 (compound 66, 0.1, 1 μM) 显著抑制了THP-1细胞和骨髓来源的巨噬细胞 (mBMDMs) 中p-RIP2)、p-p65、p-p38 和 p-JNK 水平的增加，这表明它在调节NOD1诱导的信号传导途径中具有有效性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NOD1 antagonist-2 相关抗体:
In Vivo	NOD1 antagonist-2 (compound 66, orally) 抑制免疫细胞和上皮细胞中炎症细胞因子 (IL-6, TNF-α) 和化学趋化因子 (CXCL1, CXCL8) 的表达，以及在幽门螺杆菌诱导的小鼠模型中炎症细胞因子 (KC, IL-6) 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C21H13Cl2F2N3O5S2
Molar Mass	560.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xinhua Liu, et al. Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection. J Med Chem. 2024 Dec 26;67(24):22145-22167.

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