| Bioactivity | NOC-5 is a diazeniumdiolate compound that belongs to the same family of NO donors[1]. |
| Invitro | NOC-5 (5-20 μM) in PBS led to a rapid increase in NO release on day one[1].NOC-5 (100 μM, 24 h) activates only caspase-3; an increase in caspase-3 activity occurred after NO donor treatment: 1.62 (1.57-1.66) (P < 0.05). NOC-5 has pro-apoptotic action in Jurkat cells, but at the same time increased the level of anti-apoptotic proteins[2]. |
| Name | NOC-5 |
| CAS | 146724-82-5 |
| Formula | C6H16N4O2 |
| Molar Mass | 176.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sophie A Bradley, et al. Characterisation and comparison of temporal release profiles of nitric oxide generating donors. J Neurosci Methods. 2015 Apr 30;245:116-24. [2]. Elena G Starikova, et al. Nitric oxide donor NOC-5 increases XIAP and Aven level in Jurkat cells. Cell Biol Int. 2014 Jul;38(7):799-802. |