NNC 55-0396_product_DataBase

Bioactivity	NNC 55-0396 is a highly selective T-type calcium channel blocker with an IC50 value of 6.8 μM for Cav3.1 T-type channels. NNC 55-0396 can be used for the research of neurological disease research[1][2].
Invitro	NNC 55-0396 (0.1-1000 μM) 对 INS-1 细胞中对 HVA Ca2+ 电流无抑制作用[1]。NNC 55-0396 (1-100 μM) 在 8 μM 浓度下在 HEK 293/α1G 细胞中，阻断了 50% 以上的 T 型 Ca2+ 电流[1]。NNC 55-0396 阻断 T 型 Ca2+ 电流的 IC50 值为 6.8 μM[1]。
In Vivo	NNC 55-0396 (20 mg/kg；腹腔注射，一次) 在 GABAA 亚基 α1 缺失小鼠和 harmaline 小鼠模型中抑制震颤[1]。 Animal Model:
Name	NNC 55-0396
CAS	357400-13-6
Formula	C30H40Cl2FN3O2
Molar Mass	564.56
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Arnulfo Quesadaa, Peter H. Bui, Gregg E. Homanics，et al. Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor. European Journal of Pharmacology. 2011,659 (1): 30-36. [2]. Hideto Miwa, Jinsoo Koh, Yoshinori Kajimoto, et al. Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats. Pharmacology Biochemistry and Behavior. 2011,97(4): 656-659. [3]. Huang L, Keyser BM, Tagmose TM, et al. NNC 55-0396 [(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl]-N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride]: a new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9.

PeptideDB

NNC 55-0396

CAS: 357400-13-6 F: C30H40Cl2FN3O2 W: 564.56