| Bioactivity | NMDAR/HDAC-IN-1 (Compound 9d) is a dual NMDAR and HDAC inhibitor with a Ki of 0.59 μM for NMDAR and IC50 values of 2.67, 8.00, 2.21, 0.18 and 0.62 μM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. NMDAR/HDAC-IN-1 efficiently penetrates the blood brain barrier[1]. |
| Invitro | NMDAR/HDAC-IN-1 (Compound 9d) increases the level of AcTubulin in MV4-11 cells and rescues PC-12 cells from H2O2-induced cytotoxicity with EC50 of 0.94 μM[1]. |
| Name | NMDAR/HDAC-IN-1 |
| Formula | C22H28N2O3 |
| Molar Mass | 368.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. He F, et al. Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104109. |