| Bioactivity | NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates Caspase-1 in THP1 cells[1]. |
| Name | NLRP3 agonist 2 |
| Formula | C14H15N7 |
| Molar Mass | 281.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. O' Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518. [2]. O' Donovan DH, et al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129518. |