| Bioactivity | NLRP3-IN-55 (Compound 19) is a potent NLRP3 inhibitor (IC50 = 0.34 μM). NLRP3-IN-55 directly targets the NLRP3 protein (KD = 0.45 μM), blocking the assembly and activation of the NLRP3 inflammasome, leading to anti-inflammatory effects and inhibition of cellular pyroptosis[1]. |
| Formula | C32H30ClFN2O4 |
| Molar Mass | 561.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kang T, et al. Design, synthesis and biological evaluation of novel diphenylamine analogues as NLRP3 inflammasome inhibitors. Bioorg Med Chem. 2024 Nov 1;113:117927. |