| Bioactivity | NLRP3-IN-46 (Compound 3k) activates neuro-immunomodulatory cholinergic anti-inflammatory pathway, and thus inhibits NLRP3 inflammasome activation. NLRP3-IN-46 inhibits Uric acid sodium (HY-B2130A)-induced IL-1β production in THP-1 cells, and can be used in gouty arthritis research[1]. |
| Formula | C23H25BrN2O |
| Molar Mass | 425.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wu HR, et al., Identification of O-arylated huperzinines as novel cholinergic anti-inflammatory pathway agonists against gout arthritis. Bioorg Chem. 2024 Nov;152:107716. |