| Bioactivity | NLRP3-IN-44 (compound P33) is a potent and orally active (approximately 62%) inhibitor of NLRP3, with the KD of 17.5 nM. NLRP3-IN-44 plays an important for studying NLRP3 inflammasome-mediated diseases[1]. |
| CAS | 3040298-34-5 |
| Formula | C25H30N4O3 |
| Molar Mass | 434.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhiyuan Fu, et al. Discovery of Potent, Specific, and Orally Available NLRP3 Inflammasome Inhibitors Based on Pyridazine Scaffolds for the Treatment of Septic Shock and Peritonitis. J Med Chem. 2024 Sep 12;67(17):15711-15737. |
NLRP3-IN-44
CAS: 3040298-34-5 F: C25H30N4O3 W: 434.53
NLRP3-IN-44 (compound P33) is a potent and orally active (approximately 62%) inhibitor of NLRP3, with the KD of 17.5 nM.
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