| Bioactivity | NLRP3-IN-42 (compound H28) is a potent NLRP3 inhibitor with an KD value of 1.15 µM. NLRP3-IN-42 decreases the LPS (HY-D1056) induced protein expression of cleaved-caspase-1 (p20). NLRP3-IN-42 selectively inhibits IL-1β release[1]. |
| Invitro | NLRP3-IN-42 (compound H28) (0-30 µM) 以剂量依赖性方式降低 LPS (HY-D1056) 诱导的 cleaved-caspase-1 (p20) 的表达[1]。NLRP3-IN-42 可以稳定地结合 NLRP3 NACHT 结构域的 ADP 活性位点[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NLRP3-IN-42 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | NLRP3-IN-42 (10 mg/kg; i.p.) 通过抑制 NLRP3 炎症小体选择性抑制 IL-1β 释放，而不会显著影响炎症因子 TNF-α[1]。药代动力学分析 (ICR mice)[1]. PK parameters |
| Formula | C29H27F3N2O3S2 |
| Molar Mass | 572.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang C, et al. Discovery of novel biphenyl-sulfonamide analogues as NLRP3 inflammasome inhibitors. Bioorg Chem. 2024 May;146:107263. |