| Bioactivity | NLRP3-IN-28 (compound N77) is a potent inhibitor of NLRP3. NLRP3-IN-28 inhibits Nigericin (HY-127019)-induced pyroptosis with an EC50 of 0.07μM. NLRP3-IN-28 alleviates the inflammatory reaction in vivo[1]. |
| Name | NLRP3-IN-28 |
| CAS | 2922814-80-8 |
| Formula | C12H9F3N2O3S |
| Molar Mass | 318.27 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhou N, et al. Discovery of a novel pyroptosis inhibitor acting though modulating glutathionylation to suppress NLRP3-related signal pathway. Int Immunopharmacol. 2024 Jan 25;127:111314. |
NLRP3-IN-28
CAS: 2922814-80-8 F: C12H9F3N2O3S W: 318.27
NLRP3-IN-28 (compound N77) is a potent inhibitor of NLRP3. NLRP3-IN-28 inhibits Nigericin (HY-127019)-induced pyroptosis
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This product is for research use only, not for human use. We do not sell to patients.