| Bioactivity | NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis[1]. |
| Target | NLRP3 |
| In Vivo | 在小鼠中的药代动力学分析[1]Route |
| Name | NLRP3-IN-20 |
| CAS | 2428478-22-0 |
| Formula | C22H27N3O3S |
| Molar Mass | 413.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li Z, et al. Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis. J Med Chem. 2023 Sep 11.. . |
NLRP3-IN-20
CAS: 2428478-22-0 F: C22H27N3O3S W: 413.53
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β se
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