NLRP3-IN-15_product_DataBase

Bioactivity	NLRP3-IN-15 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-15 inhibits IL-1β release with an IC50 of 0.114 μM. NLRP3-IN-15 can be used for the research of inflammation[1].
Invitro	NLRP3-IN-15 (化合物 12a) 抑制 IL-1β 释放，IC50 为 0.114 μM (ELISA 测定) [1]。NLRP3-IN-15 (2 μM，3 小时) 抑制小鼠腹膜巨噬细胞 (PM) 中 IL-1β (p17) 和 caspase-1 (p20) 的分泌[1]。NLRP3-IN-15 通过抑制 ASC 寡聚化来抑制 NLRP3 炎性体复合物的形成[1]。NLRP3-IN-15 在人和小鼠肝微粒体中表现出代谢稳定性 (T1/2: 693 min; Clint: 2.0 μL/min/mg)[1]. Western Blot Analysis[1] Cell Line:
In Vivo	NLRP3-IN-15 (化合物 5j) (50 mg/kg;i.p.) 在败血症小鼠模型中表现出抗炎作用[1]。 Animal Model:
Name	NLRP3-IN-15
CAS	2767369-71-9
Formula	C22H19NO4
Molar Mass	361.39
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li J, et al. Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor. J Med Chem. 2023 Feb 23;66(4):2946-2963.

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