| Bioactivity | NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the research of dengue virus (DENV)[1]. | ||||||||||||
| Target | NS4B | ||||||||||||
| Invitro | NITD-688 shows antiviral activity against all four serotypes of dengue virus (DENV), with EC50 values of 8 to 38 nM[1].NITD-688 shows antiviral activity against DENV-2 infected PBMCs, with an EC50 value of 0.94 nM[1].NITD-688 directly binds to wild-type but not mutant NS4B protein[1]. | ||||||||||||
| In Vivo | NITD-688 (30 mg/kg, oral gavage, twice daily for 3 days) demonstrates excellent antiviral efficacy in infected AG129 mice[1].NITD-688 (15-300 mg/kg, oral gavage, per day for 7 days) is well tolerated in rats and dogs (toxicology studies)[1]. Animal Model: | ||||||||||||
| Name | NITD-688 | ||||||||||||
| CAS | 2407227-31-8 | ||||||||||||
| Formula | C25H32N4O3S2 | ||||||||||||
| Molar Mass | 500.68 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Moquin SA, et al. NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models. Sci Transl Med. 2021 Feb 3;13(579):eabb2181. |
NITD-688
CAS: 2407227-31-8 F: C25H32N4O3S2 W: 500.68
NITD-688 is an orally active pan-serotype inhibitor of the dengue virus NS4B protein. NITD-688 can be used in the resear
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