| Bioactivity | NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) [1][2]. | ||||||
| Invitro | NIM811 induces a concentration-dependent reduction of HCV RNA in the replicon cells with an IC50 of 0.66 μM at 48 h. In addition, the combination of NIM811 with alpha IFN significantly enhances anti-HCV activities without causing any increase of cytotoxicity[1]. NIM811 blocks the mitochondrial permeability transition induced by calcium and inorganic phosphate[2]. | ||||||
| Name | NIM811 | ||||||
| CAS | 143205-42-9 | ||||||
| Formula | C62H111N11O12 | ||||||
| Molar Mass | 1202.61 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Stored under nitrogen, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) |
NIM811
CAS: 143205-42-9 F: C62H111N11O12 W: 1202.61
NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophili
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