| Bioactivity | NIC3 is a selective nucleus accumbens-associated protein-1 (NAC1) inhibitor, binds to the conserved Leu-90 of NAC1, prevents its homodimerization, and leads to proteasomal NAC1 degradation. Anti-cancer activity[1]. | ||||||||||||
| Target | NAC1 | ||||||||||||
| Name | NIC3 | ||||||||||||
| CAS | 494830-67-0 | ||||||||||||
| Formula | C26H36N2O4 | ||||||||||||
| Molar Mass | 440.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Wang X, et al. Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem. 2019 May 17. pii: jbc.RA119.007664. |