| Bioactivity | NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 11 and 16 nM, respectively. NIBR189 can be used for the research of autoimmune diseases[1]. | ||||||||||||
| Invitro | NIBR189 (0-1 μM; 3 h) blocks migration of U937 cells[1].NIBR189 (0-10 μM) blocks oxysterol-dependent activation with an IC50 value of 9 nM[1]. Cell Migration Assay [1] Cell Line: | ||||||||||||
| In Vivo | 1.19Pharmacokinetic Properties of NIBR189 in Mice[1]. | ||||||||||||
| Name | NIBR189 | ||||||||||||
| CAS | 1599432-08-2 | ||||||||||||
| Formula | C21H21BrN2O3 | ||||||||||||
| Molar Mass | 429.31 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Gessier F, et al. Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor. J Med Chem. 2014 Apr 24;57(8):3358-68. |
NIBR189
CAS: 1599432-08-2 F: C21H21BrN2O3 W: 429.31
NIBR189 is an EBI2 (Epstein-Barr virus-induced gene 2) antagonist. NIBR189 inhibits human and mouse EBI2 with IC50s of 1
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