| Bioactivity | NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats[1]. |
| Target | pIC50: 6.6 (rat NHE3), 6.2 (human NHE3) |
| Name | NHE3-IN-3 |
| CAS | 543734-50-5 |
| Formula | C16H16Cl2N2O2S |
| Molar Mass | 371.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jacobs JW, et al. Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3. ACS Med Chem Lett. 2022 Apr 11;13(7):1043-1051. |
NHE3-IN-3
CAS: 543734-50-5 F: C16H16Cl2N2O2S W: 371.28
NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat
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