| Bioactivity | NF-κB-IN-9 is a nuclear factor kappa B (NF-κB) targeting sonosensitizer (λex/λem=489/628 nm). NF-κB-IN-9 exhibits strong inhibition on NF-κB signaling due to its two resveratrol units in one molecule. NF-κB-IN-9 has anti-tumor activity and shows remarkable sonocytotoxicity against cancer cells. NF-κB-IN-9 has biosafety in eenograft mice model. |
| Invitro | NF-κB-IN-9（TR2；1 nM-10 μM）在 RAW 264.7 巨噬细胞中抑制 NO 产生，EC50 值为 68.9 nm[1]。NF-κB-IN-9（10 μM；超声处理 30 秒）抑制 MCF-7 细胞增殖并诱导细胞凋亡。NF-κB-IN-9 对 MCF-7 细胞表现出声细胞毒性，在持续 30 秒、2 分钟、5 分钟超声处理时间后，IC50 分别为 1.6 μM、0.55 μM、0.29 μM[1]。 |
| In Vivo | NF-κB-IN-9（TR2；1.5 mg/kg；静脉注射；分别在第 0 天和第 10 天）在异种移植小鼠模型中显示出抗癌功效和良好的耐受性。脑内可检测到 NF-κB-IN-9 荧光，提示 TR2 可穿透血脑屏障[1]。 Animal Model: |
| Name | NF-κB-IN-9 |
| Formula | C62H50N4O4S |
| Molar Mass | 947.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li Y, et al. Design of Sonosensitizers Integrated with Resveratrol Motif for Synergetic Sonodynamic Therapy and Nuclear Factor Kappa B Transcription Suppression of Breast Cancer. J Med Chem. 2023 Apr 19. |