| Bioactivity | NF-κB-IN-18 (Compound 5k) is an orally active NF-κB inhibitor. NF-κB-IN-18 inhibits phosphorylation of p65. NF-κB-IN-18 exhibits potent anti-inflammatory activity in Xylene-induced ear edema mice[1]. |
| Invitro | NF-κB-IN-18 (10-100 μM, 12 h) 抑制 RAW264.7 细胞中 LPS (HY-D1056) 诱导的 p65 磷酸化[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NF-κB-IN-18 相关抗体: |
| In Vivo | NF-κB-IN-18 (25-100 mg/kg，腹腔注射和口服) 在二甲苯诱导的小鼠耳水肿试验中表现出强大的抗炎活性，其中腹腔给药后抑制率为 81.77%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C29H28N2O6 |
| Molar Mass | 500.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gao YL, et al. Mollugin Derivatives as Anti-Inflammatory Agents: Design, Synthesis, and NF-κB Inhibition. Chem Biol Drug Des. 2024 Dec;104(6):e70024. |