| Bioactivity | NF-κB-IN-12 (compound 3h) is a potent NF-κB inhibitor, with an IC50 of 1.02 μM. NF-κB-IN-12 can be used for acute lung injury research[1]. |
| Target | IC50: 1.02 ± 0.29 μM (NF-κB) |
| Invitro | NF-κB-IN-12 (compound 3h) 对 MCF-12A 细胞(正常上皮细胞)无毒性[1]。 0 --> NF-κB-IN-12 相关抗体: |
| In Vivo | NF-κB-IN-12 (compound 3h) (5-10 mg/kg，IP，每日)对 SD 大鼠显示出对 CLP (盲肠结扎穿刺)方法诱导的脓毒症的保护作用[1]。 Animal Model: |
| Name | NF-κB-IN-12 |
| Formula | C30H26N6O5S |
| Molar Mass | 582.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zang B, et al. Synthesis and protective effect of pyrazole conjugated imidazo[1,2-a]pyrazine derivatives against acute lung injury in sepsis rats via attenuation of NF-κB, oxidative stress, and apoptosis. Acta Pharm. 2023 Sep 14;73(3):341-362. |