| Bioactivity | NEK7-IN-2 (compound 23) is a potent inhibitor of NLRP3-NEK7 interaction. NEK7-IN-2 can enhance the thermal stability of NEK7 and regulatie NLRP3 inflammasome assembly. NEK7-IN-2 inhibits IL-1β releases[1]. |
| Formula | C27H28F4N6O2 |
| Molar Mass | 544.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang L, et, al. Discovery of novel biaryl urea derivatives against IL-1β release with low toxicity based on NEK7 inhibitor. Eur J Med Chem. 2024 Dec 3:283:117125. |