NE-100 hydrochloride

CAS: 149409-57-4 F: C23H34ClNO2 W: 391.97

NE-100 (hydrochloride) isa potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochlori

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Bioactivity	NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo[1]. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death[2].
Name	NE-100 hydrochloride
CAS	149409-57-4
Formula	C23H34ClNO2
Molar Mass	391.97
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Ono Y, et al. A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochem Biophys Res Commun. 2013 May 17;434(4):904-9. [2]. Okuyama S, et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 1993;53(18):PL285-90.