| Bioactivity | NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC50 of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity[1]. |
| Invitro | NDT-30805 (0-2 μM; 30 min) inhibits IL-1β release in PBMCs[1].NDT-30805 (0-2 μM; 30 min) inhibits ASC speck formation in THP1-ASC-GFP cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | NDT-30805 |
| Formula | C23H22N6S |
| Molar Mass | 414.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. David H, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Medicinal Chemistry Letters. 2022. |