| Bioactivity | NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC50 value of 66 nM in the PBMC method and 4.7 μM in the WB method. NDT-19795 is a carboxylic acid-active substance that can be converted from NT-0796 (HY-156438) within cells. NDT-19795 can be used for the study of neurological diseases[1]. |
| Target | IC50: 66 nM (NLRP3 inflammasome, PBMC).IC50: 4.7 μM (NLRP3 inflammasome; WB). |
| In Vivo | NDT-19795 (3 mg/kg; 静脉注射; 单剂量) 在 C57BL/6 小鼠中的脑血比为 0.07 ，血脑屏障透过性较低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 2272917-12-9 |
| Formula | C20H21N3O4 |
| Molar Mass | 367.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Harrison D, et al. Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders. J Med Chem. 2023;66(21):14897-14911. |
NDT-19795
CAS: 2272917-12-9 F: C20H21N3O4 W: 367.40
NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC50 value of 66 nM in the PBMC method and 4.7 μM
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