| Bioactivity | NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation[1]. |
| Target | Pim-1 |
| In Vivo | NDBM 在正常细胞 (HUVEC、RAW 264.7细胞系) 中的荧光强度低于肿瘤细胞 (MGC-803、HepG2 和Hela 细胞系) [1]。NDBM (2.5、5、10和20 μM, 18 h) 降低肿瘤细胞 (MGC-803、HepG 2和 Hela) 的存活率[1]。 |
| Name | NDBM |
| Formula | C33H35BrN4O7 |
| Molar Mass | 679.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu C, et al. Multifunctional Theranostic Probe Based on the Pim-1 Kinase Inhibitor with the Function of Tracking pH Fluctuations during Treatment. Anal Chem. 2023;95(31):11732-11740. |