| Bioactivity | ND1-YL2 is a PROTAC that selectively degrades SRC-1 via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research[1]. |
| Target | SRC-1. |
| Name | ND1-YL2 |
| CAS | 2582803-80-1 |
| Sequence | Arg-Leu-Ala-Ala-Ala-Ala-Leu-Leu-Pro-Pro-Thr-Glu-Gln-Asp-Leu-{S-2(4-Pentenyl)Ala}-Lys-Leu-{(Cyclohexyl)Ala}-{S-2(4-Pentenyl)Ala}-Tyr-NH2 |
| Shortening | RLAAAALLPPTEQDL-{S-2(4-Pentenyl)Ala}-KL-{(Cyclohexyl)Ala}-{S-2(4-Pentenyl)Ala}-Y-NH2 |
| Formula | C114H189N27O28 |
| Molar Mass | 2385.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee Y, et al. Targeted Degradation of Transcription Coactivator SRC-1 through the N-Degron Pathway. Angew Chem Int Ed Engl. 2020 Sep 28;59(40):17548-17555. |
ND1-YL2
CAS: 2582803-80-1 F: C114H189N27O28 W: 2385.88
ND1-YL2 is a PROTAC that selectively degrades SRC-1 via the N-degron pathway. ND1-YL2 significantly inhibits cancer inva
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