| Bioactivity | ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1]. |
| Target | 0.12 μM (respiratory complex I), 2.47 (bo3 oxidase), 0.63 (bd-I oxidases), 1.3 (bd-II oxidases) |
| Invitro | ND-011992 对牛心脏线粒体膜 NADH 氧化酶活性有抑制作用，IC50 为 3.27 µM[1]。 0 --> ND-011992 相关抗体: |
| Name | ND-011992 |
| CAS | 2446880-46-0 |
| Formula | C21H14F3N3O |
| Molar Mass | 381.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kägi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13(1):12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w |
ND-011992
CAS: 2446880-46-0 F: C21H14F3N3O W: 381.35
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011
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