| Bioactivity | NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves' disease[1]. | ||||||||||||
| Name | NCGC00229600 | ||||||||||||
| CAS | 1338824-20-6 | ||||||||||||
| Formula | C30H29N3O3 | ||||||||||||
| Molar Mass | 479.57 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Neumann S, et al. A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54. |
NCGC00229600
CAS: 1338824-20-6 F: C30H29N3O3 W: 479.57
NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimula
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