| Bioactivity | NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms[1]. |
| In Vivo | NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition[1]. Animal Model: |
| Name | NCC007 |
| CAS | 2342583-66-6 |
| Formula | C22H28F3N7 |
| Molar Mass | 447.50 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998. |