| Bioactivity | NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC50=40 nM). By inhibiting the activity of LDH, NCATS-SM1441 is able to reduce the production of lactic acid in cancer cells, helping to slow or stop the proliferation of cancer cells. NCATS-SM1441 can be used to study cancer metabolism[1]. |
| CAS | 1964517-04-1 |
| Formula | C31H25FN4O4S3 |
| Molar Mass | 632.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rai G, et al. Pyrazole-based lactate dehydrogenase inhibitors with optimized cell activity and pharmacokinetic properties[J]. Journal of medicinal chemistry, 2020, 63(19): 10984-11011. |
NCATS-SM1441
CAS: 1964517-04-1 F: C31H25FN4O4S3 W: 632.75
NCATS-SM1441 (compound 52) is a lactate dehydrogenase (LDH) inhibitor (IC50=40 nM). By inhibiting the activity of LDH, N
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