| Bioactivity | NC-190 is an inhibitor for topoisomerase II, that stabilizes the cleavable complex of DNA topoisomerase II with DNA, and leads to DNA fragmentation. NC-190 exhibits board-spectrum cytotoxicity in cancer cells. NC-190 exhibits antitumor efficacy in mice[1][2]. |
| CAS | 120602-99-5 |
| Formula | C23H21N4NaO5 |
| Molar Mass | 456.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nakaike S, et al., In vivo activity on murine tumors of a novel antitumor compound, N-beta-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxybenzo[a]phenazine-6-carboxamide sodium salt (NC-190). Cancer Chemother Pharmacol. 1989;23(3):135-9. [2]. Yamagishi T, et al., A novel antitumor compound, NC-190, induces topoisomerase II-dependent DNA cleavage and DNA fragmentation. Cancer Chemother Pharmacol. 1996;38(1):29-34. |