| Bioactivity | NBI 35965 hydrochloride (Compound 12a) is a functional corticotropin-releasing factor (CRF1) receptor antagonist with a pKi value of 8.5. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride penetrates the blood-brain barier and is orally active[1]. |
| Name | NBI 35965 hydrochloride |
| CAS | 1782228-59-4 |
| Formula | C21H23Cl3N4 |
| Molar Mass | 437.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gross RS, et al. Design and synthesis of tricyclic corticotropin-releasing factor-1 antagonists. J Med Chem. 2005 Sep 8;48(18):5780-93. |
NBI 35965 hydrochloride
CAS: 1782228-59-4 F: C21H23Cl3N4 W: 437.79
NBI 35965 hydrochloride (Compound 12a) is a functional corticotropin-releasing factor (CRF1) receptor antagonist with a
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.