| Bioactivity | NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research. |
| Invitro | NBI-34041 可以以浓度依赖性方式抑制 cAMP 的产生，IC50 约为 60 nM。当 NBI-34041 浓度高达 10 000 nM 时，NBI-34041 无法完全抑制表达人类 CRF2 受体的细胞中 sauvagine 刺激的 cAMP[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NBI-34041 相关抗体: |
| In Vivo | NBI-34041（3-30 mg/kg；口服管饲；单剂量）可显著减轻 CRF 引起的血浆 ACTH 升高。NBI-34041 还显示出以剂量依赖性方式减轻休克引起的 ACTH 释放的功效[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 268545-87-5 |
| Formula | C22H26Cl2N4 |
| Molar Mass | 417.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Marcus Ising, et al. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology. 2007 Sep;32(9):1941-9. |
NBI-34041
CAS: 268545-87-5 F: C22H26Cl2N4 W: 417.37
NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a
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