| Bioactivity | NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC50s of 80 nM and 850 nM, respectively[1]. |
| Name | NBC19 |
| CAS | 2068818-75-5 |
| Formula | C24H26BCl3N2O2 |
| Molar Mass | 491.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Redondo-Castro E, et al. Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses. Sci Rep. 2018 Apr 4;8(1):5667. |
NBC19
CAS: 2068818-75-5 F: C24H26BCl3N2O2 W: 491.65
NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- a
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