| Bioactivity | NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo[1]. | ||||||||||||
| Invitro | M22 (0.37-90 μM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells[1].M22 (0.1-100 μM; 48 h) inhibits A549 cell proliferation completely at 30 µM (GI50=5.5 µM, GI90=19.3 µM)[1].M22 (15-30 μM; 36 h) promotes apoptosis in A549 cell line[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | NAE-IN-M22 | ||||||||||||
| CAS | 864420-54-2 | ||||||||||||
| Formula | C20H24Cl2N2 | ||||||||||||
| Molar Mass | 363.32 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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NAE-IN-M22
CAS: 864420-54-2 F: C20H24Cl2N2 W: 363.32
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar
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