| Bioactivity | NAE-IN-1 (compound X-10) is a potent NAE1 inhibitor. NAE-IN-1 induces apoptosis and cell cycle arrest at the G2/M phase. NAE-IN-1 increases ROS levels and prevents cell migration. NAE-IN-1 shows anti-proliferation activity[1]. |
| Invitro | NAE-IN-1 (compound X-10) (1, 3, 5 µM; 24 h) 以剂量依赖性方式降低 MGC-803 细胞中 Cullin 1 和 Cullin 3 的表达[1].NAE-IN-1 (0, 1, 2, 4 µM; 24 h) 可诱导细胞周期停滞在 G2/M 期[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> NAE-IN-1 相关抗体: Cell Proliferation Assay[1] Cell Line: |
| Formula | C29H30N4O2S |
| Molar Mass | 498.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang X, et al. Identification of novel benzothiazole derivatives as inhibitors of NEDDylation pathway to inhibit the progression of gastric cancer. Bioorg Med Chem Lett. 2024 Mar 1;100:129647. |