| Bioactivity | NA-Ir is a ferroptosis inducer. NA-Ir induces ferroptinophagy by targeting mitochondrial DNA (mtDNA) and activating the cGAS-STING pathway, while also triggering the production of reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), leading to lipid peroxidation and ferroptosis (Ferroptosis). NA-Ir exhibits higher anticancer activity under light irradiation and selectively inhibits cancer cells with high H2S levels[1]. |
| CAS | 3031762-97-4 |
| Formula | C49H36F6IrN8O4P |
| Molar Mass | 1138.04 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li Y, et al. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy. J Med Chem. 2024 Sep 26;67(18):16235-16247. |
NA-Ir
CAS: 3031762-97-4 F: C49H36F6IrN8O4P W: 1138.04
NA-Ir is a ferroptosis inducer. NA-Ir induces ferroptinophagy by targeting mitochondrial DNA (mtDNA) and activating the
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