| Bioactivity | Peroxisome proliferator-activated receptors (PPARs) play an important role in regulating lipid and glucose metabolism, and oleoylethanolamide (OEA) is a natural ligand for PPARα. N-Octadecyl-N'-propyl-sulfamide is an analog of OEA and a potent activator of PPARα, with selective binding affinity for PPARα (EC50=100 nM, compared to 120 nM for OEA). N-Octadecyl-N'-propyl-sulfamide (10 mg/kg; ip) inhibits food intake and reduces body weight gain in rats. At a dose of 1 mg/kg, N-Octadecyl-N'-propyl-sulfamide induces satiety, thereby reducing food intake, body weight, and plasma triglyceride concentrations in free-feeding Wistar rats and obese Zucker (fa/fa) rats. |
| CAS | 925891-74-3 |
| Formula | C21H46N2O2S |
| Molar Mass | 390.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. de Fonseca, et al. An anorexic lipid mediator regulated by feeding. Nature 414(6860), 209-212 (2001). |
N-Octadecyl-N'-propyl-sulfamide
CAS: 925891-74-3 F: C21H46N2O2S W: 390.67
Peroxisome proliferator-activated receptors (PPARs) play an important role in regulating lipid and glucose metabolism, a
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