| Bioactivity | N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research[1][2]. | ||||||||||||
| In Vivo | 1.19Pharmacokinetic Parameters of N-Deshydroxyethyl Dasatinib in Wistar Rats[2]. Analyte | ||||||||||||
| Name | N-Deshydroxyethyl Dasatinib | ||||||||||||
| CAS | 910297-51-7 | ||||||||||||
| Formula | C20H22ClN7OS | ||||||||||||
| Molar Mass | 443.95 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. [2]. Thappali SR, et al. Simultaneous determination of methotrexate, dasatinib and its active metabolite N- deshydroxyethyl dasatinib in rat plasma by LC-MS/MS: method validation and application to pharmacokinetic study. Arzneimittelforschung. 2012 Dec;62(12):624-30. |
N-Deshydroxyethyl Dasatinib
CAS: 910297-51-7 F: C20H22ClN7OS W: 443.95
N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inh
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