N-Deshydroxyethyl Dasatinib_product_DataBase

Bioactivity

N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research[1][2].

In Vivo

1.19Pharmacokinetic Parameters of N-Deshydroxyethyl Dasatinib in Wistar Rats[2]. Analyte

Name

N-Deshydroxyethyl Dasatinib

CAS

910297-51-7

Formula

C20H22ClN7OS

Molar Mass

443.95

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. [2]. Thappali SR, et al. Simultaneous determination of methotrexate, dasatinib and its active metabolite N- deshydroxyethyl dasatinib in rat plasma by LC-MS/MS: method validation and application to pharmacokinetic study. Arzneimittelforschung. 2012 Dec;62(12):624-30.

PeptideDB

N-Deshydroxyethyl Dasatinib

CAS: 910297-51-7 F: C20H22ClN7OS W: 443.95