| Bioactivity | N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria[1][2]. | ||||||||||||
| Invitro | N-Desethyl amodiaquine dihydrochloride has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively[1]. | ||||||||||||
| Name | N-Desethyl amodiaquine | ||||||||||||
| CAS | 79352-78-6 | ||||||||||||
| Formula | C18H18ClN3O | ||||||||||||
| Molar Mass | 327.81 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [2]. Xue-Qing Li, et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407. |
N-Desethyl amodiaquine
CAS: 79352-78-6 F: C18H18ClN3O W: 327.81
N-Desethyl amodiaquine is the biologically active metabolite ofAmodiaquine(HY-B1322A). N-Desethyl amodiaquine is an anti
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