N-Desethyl amodiaquine_product_DataBase

Bioactivity

N-Desethyl amodiaquine is the biologically active metabolite of Amodiaquine (HY-B1322A). N-Desethyl amodiaquine is an antiparasitic agent, has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively. N-Desethyl amodiaquine can be used for the research of malaria[1][2].

Invitro

N-Desethyl amodiaquine dihydrochloride has inhibitory for strains V1/S and 3D7 with IC50 values of 97 nM and 25 nM, respectively[1].

Name

N-Desethyl amodiaquine

CAS

79352-78-6

Formula

C18H18ClN3O

Molar Mass

327.81

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82. [2]. Xue-Qing Li, et al. Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate. J Pharmacol Exp Ther. 2002 Feb;300(2):399-407.

PeptideDB

N-Desethyl amodiaquine

CAS: 79352-78-6 F: C18H18ClN3O W: 327.81