| Bioactivity | N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity. | ||||||||||||
| Invitro | N-Bis(2-hydroxypropyl)nitrosamine is an agent with carcinogenic activity[1]. | ||||||||||||
| In Vivo | N-Bis(2-hydroxypropyl)nitrosamine causes the tumors to develop in the lung, liver, and thyroid of rats at a dose of 100 ppm, in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats at a dose of 500 ppm, and in the lung, liver thyroid, esophagus, kidney, and urinary bladder of rats at both doses[1]. Bisphenol A (BPA) enhances the susceptibility to thyroid carcinoma stimulated by N-Bis(2-hydroxypropyl)nitrosamine (DHPN; 2800 mg/kg) in rats[2]. | ||||||||||||
| Name | N-Bis(2-hydroxypropyl)nitrosamine | ||||||||||||
| CAS | 53609-64-6 | ||||||||||||
| Formula | C6H14N2O3 | ||||||||||||
| Molar Mass | 162.19 | ||||||||||||
| Appearance | Liquid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Konishi Y, et al. Effect of dose on the carcinogenic activity of orally administered N-bis(2-hydroxypropyl)nitrosamine in rats. Gan. 1978 Aug;69(4):573-7. [2]. Zhang J, et al. Low dose of Bisphenol A enhance the susceptibility of thyroid carcinoma stimulated by DHPN and iodine excess in F344 rats. Oncotarget. 2017 Jul 22;8(41):69874-69887. |