| Bioactivity | N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration[1][2]. |
| Invitro | N-Arachidonylglycine (0.1 nM-100 µM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells[1].N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm[2]. Western Blot Analysis[1] Cell Line: |
| Name | N-Arachidonylglycine |
| CAS | 179113-91-8 |
| Formula | C22H35NO3 |
| Molar Mass | 361.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
N-Arachidonylglycine
CAS: 179113-91-8 F: C22H35NO3 W: 361.52
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 4
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