Bioactivity | Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL. |
CAS | 120243-02-9 |
Formula | C20H24N2O7 |
Molar Mass | 404.41 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Kunze, et al. Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties. J. Antibiot. (Tokyo) 42(1), 14-17 (1989). |