| Bioactivity | Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome c release, PARP-cleavage and phosphorylation of JNK, increases Bax and cleaved caspase-3, -5, and -8 levels. Myrothecine A has anticancer activities and promotes the maturation of DC cells in the microenvironment. Myrothecine A inhibits proliferation of A549, MCF-7, HepG2, and SMMC-7721 cancer cells with IC50s of 95, 70, 60, and 25 µM, respectively[1][2][3]. |
| CAS | 910292-40-9 |
| Formula | C29H38O10 |
| Molar Mass | 546.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. 1.Fu Y, et al. Myrothecine A modulates the proliferation of HCC cells and the maturation of dendritic cells through downregulating miR-221. Int Immunopharmacol. 2019 Oct;75:105783. [2]. 2.Lin T, et al. Structure elucidation and biological activity of two new trichothecenes from an endophyte, Myrothecium roridum. J Agric Food Chem. 2014 Jun 25;62(25):5993-6000. [3]. 3.Song H, et al. Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. Molecules. 2019 Jun 20;24(12):2291. |
Myrothecine A
CAS: 910292-40-9 F: C29H38O10 W: 546.61
Myrothecine A is a trichothecene mycotoxin found in M. roridum. Myrothecine A induces apoptosis, promotes the cytochrome
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