| Bioactivity | Myrcene-13C3 is 13C labeled trans-2-Decenal (HY-W015551). trans-2-Decenal is an important raw material and intermediate used in organic synthesis, medicine, pesticides and dyes. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Myrcene（50 μM, 100 μM；24 h, 48 h）通过导致 MDA-MB-231 细胞中 IKK 失活来抑制 TNFα (10 ng/mL) 诱导的 NF-κB 活性[3]。Myrcene（0.25-1.0 μg/mL；24 小时、48 小时）抑制 A549 细胞中克隆球的形成，并将细胞周期阻滞在 G0/G1 期，导致细胞凋亡[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Myrcene-13C3 相关抗体: |
| In Vivo | Myrcene (100 mg/kg, 200 mg/kg; 腹腔注射; 30 天) 能够改善 AlCl3 (5 mg/kg; p. o.) 和 D-galactose (60 mg/kg; i. p.) 对小鼠的神经行为和神经病理学影响[5]。肾上腺切除术 (ADX) 已被证明会通过炎症和氧化应激加剧肾损伤，从而导致 GC 耗竭导致肾损伤。Myrcene（100 mg/kg；腹腔注射；14 天）可减轻 ADX 大鼠模型中的肾脏炎症和氧化应激[6]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C713C3H16 |
| Molar Mass | 139.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Eunson Hwang, et al. Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production. Am J Chin Med. 2017;45(5):1113-1124. [3]. Jeong-Ho Lee, et al. Anti-invasive effect of β-myrcene, a component of the essential oil from Pinus koraiensis cones, in metastatic MDA-MB-231 human breast cancer cells. Journal of the Korean Society for Applied Biological Chemistry volume 58, pages563–569. [4]. Bai X, et al. Myrcene exhibits antitumor activity against lung cancer cells by inducing oxidative stress and apoptosis mechanisms[J]. Natural Product Communications, 2020, 15(9): 1934578X20961189. [5]. Islam AUS, et al. Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model. Molecules. 2020 Sep 30;25(19):4492. [6]. Kumar R, et al. Ameliorative effect of myrcene in mouse model of Alzheimer's disease. Eur J Pharmacol. 2021 Nov 15;911:174529. |