| Bioactivity | Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows acute inhibition of myosin V. Myosin V-IN-1 slows the actin-activated myosin V ATPase by specifically inhibiting ADP release from the actomyosin complex[1][2]. |
| Invitro | Myosin V-IN-1 (compound 8) 显示出单头肌球蛋白 V 稳态肌动蛋白激活 ATP 水解速率的剂量依赖性降低[1]。 |
| Name | Myosin V-IN-1 |
| CAS | 1259177-59-7 |
| Formula | C29H26N6O3S |
| Molar Mass | 538.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maschi D, et al. Myosin V Regulates Spatial Localization of Different Forms of Neurotransmitter Release in Central Synapses. Front Synaptic Neurosci. 2021 Apr 15;13:650334. [2]. Islam K, et al. A myosin V inhibitor based on privileged chemical scaffolds. Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8. |
Myosin V-IN-1
CAS: 1259177-59-7 F: C29H26N6O3S W: 538.62
Myosin V-IN-1 (compound 8) is a potent and selective Myosin V inhibitor, with a Ki of 6 μM. Myosin V-IN-1 shows ac
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