| Bioactivity | Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research[1]. |
| Name | Myosin-IN-1 |
| CAS | 849011-39-8 |
| Formula | C12H16N4OS2 |
| Molar Mass | 296.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Parijat P, et al. Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening. Nat Commun. 2023 Nov 24;14(1):7692. |
Myosin-IN-1
CAS: 849011-39-8 F: C12H16N4OS2 W: 296.41
Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the bi
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